G.I. Joe has been the title of comic strips and comic books in every decade since 1942. As a licensed property by Hasbro, comics have been released from 1967 to present, with only two interruptions longer than a year (1977–1981, 1997–2000). As a team fighting Cobra since 1982, the comic book history of G.I. Joe: A Real American Hero has been covered by three separate publishers and four main-title series, all of which have been based on the Hasbro toy line of the same name.

The first series was produced by Marvel Comics between 1982 and 1994, running for 155 issues, and spawning several spin-off titles throughout the course of its run; the second and third series, published by Devil's Due Productions from 2001 to 2008, totaled 80 issues and included several spin-off titles as well. The fourth series has been published by IDW Publishing since October 2008, and various spin-off titles have also been launched.